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Tofanib XR 11mg 10Pcs
- Tofacitinib is indicated for the treatment of moderate to severely active rheumatoid arthritis in adults who have not responded to or are intolerant to methotrexate. It can be used alone or in combination with methotrexate or other non-biologically modifying anti-rheumatic medications (DMARDs).
- It is also indicated for the treatment of active psoriatic arthritis in adults who have a poor response or intolerance to methotrexate or other DMARDs.
- Approved for the treatment of moderate to severe active ulcerative colitis in adults.
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✅ Description:
- Tofanib XR is used to treat moderate to severe rheumatoid arthritis.
- It helps reduce pain, tenderness, and swelling in the joints by decreasing inflammation.
- Slows the progression of bone and joint damage.
- Tofanib XR may be prescribed alone or in combination with another medicine.
- Tablets can be taken with or without food, preferably at the same time each day.
- The dosage depends on the patient's condition and concurrent medications.
- Do not discontinue without a doctor's advice to prevent the worsening of the condition.
- Blood tests may be required before starting Tofanib XR 11mg.
- Do not start if there is any ongoing infection.
- Prior consultation with the doctor is essential if you have a history of tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots.
- Increased susceptibility to infections; avoid contact with individuals having contagious diseases.
- Not suitable for children under 18 years old.
- Avoid use during pregnancy or breastfeeding unless the doctor deems the benefit outweighs the risk.
- Periodic medical examinations may be necessary.
Safety Advices
Alcohol
UNSAFE
- Consuming alcohol with Tofanib XR 11mg does not cause harmful side effects.
- However, it is advisable to check with a healthcare professional for personalized advice.
Pregnancy
CONSULT YOUR DOCTOR
- Tofanib XR 11mg may be unsafe during pregnancy.
- Limited human studies; and animal studies indicate potential harm to the developing baby.
- Benefits and risks should be assessed by the doctor before prescribing. Consultation is crucial.
Breastfeeding
CONSULT YOUR DOCTOR
- Tofanib XR 11mg is likely unsafe during breastfeeding.
- Limited human data suggests potential harm to the baby via breast milk.
- Consultation with a healthcare provider is recommended.
Driving
SAFE
Tofanib XR 11mg typically does not affect the ability to drive.
Kidney
CONSULT YOUR DOCTOR
- No specific data is available regarding the impact on kidney and liver function.
- Consultation with a doctor is advised before consuming the drug.
Liver
CONSULT YOUR DOCTOR
- No specific data is available regarding the impact on kidney and liver function.
- Consultation with a doctor is advised before consuming the drug.
Similar Products
✔️ Uses of Tofanib XR 11mg
- Rheumatoid Arthritis
✔️ Side Effects of Tofanib XR 11mg
- Common adverse reactions include upper respiratory tract infections, headache, diarrhea, and nasopharyngitis.
- Occurred in more than or equal to 2% of patients during the first 3 months of controlled clinical trials.
✔️ How does Tofanib XR 11mg work?
Tofanib XR 11mg works by blocking the action of some chemicals that cause inflammation.
✔️ Quick Suggestions:
- Take this medicine with or without food.
- Do not take in larger or smaller amounts than advised/prescribed.
- Consult the doctor if you experience any undesirable effects.
- Do not stop taking the medicine without consulting your doctor
- Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
✔️ Indications:
- Treatment of Rheumatoid arthritis
- Treatment of Psoriatic Arthritis
- Treatment of Ankylosing spondylitis
- Treatment of Ulcerative colitis
✔️ Pharmacology
- Tofacitinib is a partially reversible JAK inhibitor that prevents the body from responding to cytokine signals.
- It inhibits JAK, preventing STAT phosphorylation and activation, and works as an anti-inflammatory agent by inhibiting the JAK-STAT pathway.
- The JAK-STAT signaling pathway regulates cell transcription in hematopoietic and immune cell functions.
✔️ Dosage & Administration of Tofanib XR
- For rheumatoid arthritis: Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily.
- For psoriatic arthritis: Tofacitinib 5 mg twice daily or Tofacitinib 11 mg once daily (in combination with nonbiologic DMARDs).
- For ulcerative colitis: Tofacitinib 10 mg twice daily for at least 8 weeks, followed by 5 or 10 mg twice daily.
✔️ Interaction
- Interaction with CYP3A4 inhibitors (e.g., ketoconazole) may require dose adjustment.
- Cautious use of medications causes CYP3A4 inhibition and CYP2C19 inhibition.
- Rifampin and other CYP inducers may reduce clinical response.
✔️ Contraindications
Hypersensitivity to the active substance or any of the excipients.
✔️ Pregnancy & Lactation
- Pregnancy category C. Use during pregnancy only if potential benefits justify potential risks.
- Unknown if tofacitinib is excreted in human milk; the decision to stop breastfeeding or the drug should consider the importance of the drug for breastfeeding.
✔️ Precautions & Warnings
- Avoid use during active severe infections.
- Use with caution in patients at high risk of gastrointestinal perforation.
- Regular laboratory testing is advised due to potential changes in lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.
- Avoid use with live vaccines.
- Consideration of absolute lymphocyte count (ALC), absolute neutrophil count (ANC), and hemoglobin levels is necessary.
✔️ Storage Conditions
Do not store above 30°C. Keep out of children's reach.
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